Masu bincike a Jami'ar Tsakiyar Florida sun haɓaka wani maganin kashe kwayoyin cuta wanda ke iya ci gaba da kashe ƙwayoyin cuta a saman sama har zuwa kwanaki 7-binciken da zai iya zama makami mai ƙarfi akan COVID-19 da sauran ƙwayoyin cuta masu tasowa.
An buga binciken ne a wannan makon a cikin mujallar ACS Nano na American Chemical Society ta ƙungiyar ƙwararrun ƙwararrun ƙwayoyin cuta da ƙwararrun injiniya daga jami'a da kuma shugaban wani kamfanin fasaha a Orlando.
A farkon barkewar cutar, Christina Drake, tsohuwar tsohuwar UCF kuma wacce ta kafa Kismet Technologies, an yi wahayi zuwa gare ta bayan tafiya zuwa kantin kayan miya don haɓaka masu kashe ƙwayoyin cuta. Can sai ta ga wata ma’aikaciya tana fesa maganin kashe kwayoyin cuta a hannun firij sai nan take ta goge feshin.
Ta ce, "Da farko ra'ayina shi ne in samar da maganin kashe kwayoyin cuta mai sauri," in ji ta, "amma mun yi magana da masu amfani da su - kamar likitoci da likitocin hakora - don gano irin maganin da suke so da gaske. A gare su Abu mafi mahimmanci shi ne abin da ke dawwama. Za ta ci gaba da lalata manyan wuraren tuntuɓar kamar hannun kofa da benaye na dogon lokaci bayan aikace-aikacen. ”
Drake ya haɗu tare da Dokta Sudipta Seal, injiniyan kayan aikin UCF da ƙwararrun masana ilimin kimiyya, da Dr. Griff Parks, masanin ilimin halittu, masanin ilimin halittu, shugaban bincike na Makarantar Magunguna, da Dean na Burnett School of Biomedical Sciences. Tare da kudade daga Gidauniyar Kimiyya ta Kasa, Kismet Tech, da Babban Tech-Tech Corridor na Florida, masu bincike sun ƙirƙiri nanoparticle injuna maganin kashe kwayoyin cuta.
Abubuwan da ke aiki da shi shine injiniyan nanostructure da ake kira cerium oxide, wanda aka sani da kayan aikin antioxidant mai sabuntawa. Cerium oxide nanoparticles ana gyare-gyare tare da ƙaramin adadin azurfa don sa su fi tasiri a kan ƙwayoyin cuta.
"Yana aiki a cikin sunadarai da injina," in ji Seal, wanda ke nazarin nanotechnology fiye da shekaru 20. “Nanoparticles suna fitar da electrons don yin oxidize da kwayar cutar kuma su sa ta zama mara aiki. A kan injina, suma suna haɗa kansu da ƙwayar cuta kuma suna fashe sama kamar balloon mai fashewa."
Yawancin goge-goge ko feshi za su lalata saman cikin mintuna uku zuwa shida bayan amfani, amma babu sauran tasiri. Wannan yana nufin cewa saman yana buƙatar a maimaita akai-akai don kiyaye shi tsabta don guje wa kamuwa da ƙwayoyin cuta da yawa kamar COVID-19. Tsarin nanoparticle yana kiyaye ikonsa na hana ƙwayoyin cuta kuma yana ci gaba da lalata saman har zuwa kwanaki 7 bayan aikace-aikacen guda ɗaya.
"Magungunan kashe kwayoyin cuta suna nuna babban aikin rigakafin cutar kanjamau guda bakwai," in ji Parks, kuma dakin gwaje-gwajensa ne ke da alhakin gwada juriyar dabarar da kwayar cutar "kamus". "Ba wai kawai ya nuna kaddarorin antiviral game da coronaviruses da rhinoviruses ba, har ma ya tabbatar da yana da tasiri a kan wasu ƙwayoyin cuta daban-daban waɗanda ke da tsari daban-daban da rikitarwa. Muna fatan cewa tare da wannan ikon mai ban mamaki na kisa, wannan maganin zai kuma zama kayan aiki mai inganci ga sauran ƙwayoyin cuta masu tasowa."
Masana kimiyya sun yi imanin cewa wannan maganin zai yi tasiri sosai a kan yanayin kiwon lafiya, musamman ma rage yawan cututtukan da aka samu a asibiti-kamar methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa da Clostridium difficile -Wadannan zasu haifar da cututtuka da suka shafi fiye da haka. kashi daya bisa uku na marasa lafiya da aka kwantar a asibitocin Amurka.
Ba kamar yawancin magungunan kashe kwayoyin cuta na kasuwanci ba, wannan dabarar ba ta ƙunshi sinadarai masu cutarwa ba, wanda ke nuna cewa ba shi da haɗari a yi amfani da shi akan kowace ƙasa. Dangane da buƙatun Hukumar Kare Muhalli ta Amurka, gwaje-gwaje na tsari akan hanin fata da ƙwayoyin ido bai nuna wani illa mai cutarwa ba.
Drake ya ce "Da yawa daga cikin magungunan kashe kwayoyin cuta na gida a halin yanzu suna dauke da sinadarai masu cutarwa ga jiki bayan an maimaita bayyanar su." "Kayayyakinmu na tushen nanoparticle za su sami babban matakin aminci, wanda zai taka muhimmiyar rawa wajen rage yawan fallasa ɗan adam ga sinadarai."
Ana buƙatar ƙarin bincike kafin samfurori su shiga kasuwa, wanda shine dalilin da ya sa mataki na gaba na bincike zai mayar da hankali kan ayyukan ƙwayoyin cuta a aikace-aikace masu amfani a wajen dakin gwaje-gwaje. Wannan aikin zai yi nazarin yadda abubuwan da ke waje kamar zafin jiki ko hasken rana ke shafar abubuwan kashe ƙwayoyin cuta. Ƙungiyar tana tattaunawa tare da cibiyar sadarwa na asibiti don gwada samfurin a cikin wuraren su.
Drake ya kara da cewa: "Muna kuma binciken ci gaban fim na dindindin don ganin ko za mu iya rufewa da rufe benaye na asibiti ko hannayen ƙofa, wuraren da ke buƙatar kamuwa da cuta, ko ma wuraren da ke ci gaba da hulɗa da juna."
Seal ya shiga Sashen Kimiyya da Injiniya ta UCF a cikin 1997, wanda ke cikin Makarantar Injiniya da Kimiyyar Kwamfuta ta UCF. Yana hidima a makarantar likitanci kuma memba ne na ƙungiyar prosthetic UCF Biionix. Shi ne tsohon darektan Cibiyar Kimiyya da Fasaha ta UCF Nano da Cibiyar Kula da Kayan Aiki da Ci gaba. Ya sami digiri na uku a fannin injiniyan kayan aiki daga Jami'ar Wisconsin, tare da ƙarami a fannin ilimin halittu, kuma mai bincike ne na gaba da digiri a Laboratory National Lawrence Berkeley a Jami'ar California, Berkeley.
Bayan ya yi aiki a Makarantar Magunguna ta Wake Forest na shekaru 20, Parkes ya zo UCF a cikin 2014, inda ya yi aiki a matsayin farfesa kuma shugaban Sashen Microbiology da Immunology. Ya samu Ph.D. a Biochemistry daga Jami'ar Wisconsin kuma mai bincike ne na Ƙungiyar Ciwon Kankara ta Amirka a Jami'ar Arewa maso Yamma.
Candace Fox, mai binciken digiri na biyu daga Makarantar Magunguna ta UCF, Craig Neal daga Makarantar Injiniya da Kimiyyar Kwamfuta ta UCF, da ɗaliban da suka kammala digiri Tamil Sakthivel, Udit Kumar, da Yifei Fu daga Makarantar Injiniya da Kwamfuta ta UCF ne suka rubuta wannan binciken. .
Kayayyakin da Jami'ar Central Florida ta bayar. Asalin aikin na Christine Senior ne. Lura: Ana iya gyara abun ciki bisa ga salo da tsayi.
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Lokacin aikawa: Satumba-10-2021